Non-invasive ventilation trial in ALS Jaydeep M. Bhatt, M.D. At the Eleanor and Lou Gehrig ALS/MDA Center we see a number of ALS patients that report shortness of breath with minimal exercise or at rest. After an evaluation of lung function, we may decide to start non-invasive ventilation (NIV) in the form of a bi-level positive airway pressure. Use of NIV in ALS patient populations has been associated with improved survival and quality of life. In addition the NIV device is portable, easy to use, and conserves energy in patients with daytime fatigue when used properly. Often, we will recommend starting NIV at night during sleep. We are working with Dr. Robert Basner’s pulmonary team at Columbia and actively enrolling ALS patients who use NIV devices at night to investigate oxygen levels during sleep. The goal of the study is to determine factors that affect oxygen levels of ALS patients during sleep. Enrolled patients will receive a sleep study in their home and further evaluation from the pulmonary team if inadequate oxygen levels are identified at no additional cost. There are no specific risks associated with this trial. To be eligible, patients must use NIV at least four hours per night for at least four days per week and follow up at the Columbia ALS Center regularly. This is a great opportunity for our patients to participate in current research and receive expert services at no cost. If you or someone you know or care for may be interested in participating please e-mail alscenter@columbia.edu.