Telephone: 212-305-1319 || Email: alscenter@columbia.edu

RESEARCH: Clinical Research

Clinical Trials

In order to be enrolled in a clinical trial at the ALS Center you must be able to visit the ALS Center as determined by the clinical trial protocol.

If you are able to be evaluated at the Center and are interested in participating in a trial, please contact us at alscenter@columbia.edu or 212-305-2027.

General inquiries regarding clinical trials and results from clinical trials cannot be obtained at the Center.

CURRENT PROJECTS:

STUDY	SPONSOR	DESCRIPTION
A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study of the Safety and Efficacy of Dexpramipexole in Subjects With Amyotrophic Lateral Sclerosis	Biogen Pharmaceuticals, Inc.	Description of study www.clinicaltrials.gov
A Phase 2 Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of NP001 in Subjects With Amyotrophic Lateral Sclerosis (ALS)	Neuraltus Pharmaceuticals, Inc.	Description of study www.clinicaltrials.gov
Multicenter ALS Cohort Study of Oxidative Stress and Disease Progression	National Institute of Health	Description of study
Multicenter PLS Cohort Study of Oxidative Stress and Disease Progression	Spastic Paralegia Foundation	Description of study
Epigenetics in Health Controls	MDA	Description of study
Clinically Meaningful Changes Scale in the MDA/ALS Clinical Network	MDA	Description of study
Tracheostomy with Invasive Ventilation for Patients with ALS in Japan and the USA: A Comparative Study	MDA	Description of study
High Fat/High Calorie Study	MDA	Description of study
Clinical Trial of Ceftriaxone in Subjects with ALS	National Institute of Health	Description of study
Pilot Study of Magnetic Resonance Spectroscopy for Patients with ALS	MDA, Ride for Life	Description of study
Opto-Electronic Plethysmography (OEP) Study	MDA	Description of study
Cognitive and Behavioral Evaluation of Patients with ALS		Description of study

COMPLETED PROJECTS:

STUDY	SPONSOR	DESCRIPTION
Non-Invasive Ventilation in ALS	Wings Over Wallstreet, ALSA, Stony Wald-Herbert foundation	Description of study
A Multinational, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Assess the Efficacy, Tolerability and Safety of Talampanel in Subjects with ALS	Teva Pharmaceuticals	Description of study
A Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Assess the Safety and Efficacy, and to Determine the Pharmacokinetics of Two Doses of AVP-923 (Dextromethorphan/Quinidine) in the Treatment of Pseudobulbar Affect (PBA) in Patients with Amyotrophic Lateral Sclerosis and Multiple Sclerosis	Avanir Pharmaceuticals	Description of study
A Multicenter, Double-Blind, Placebo-Controlled, Study to Investigate the Safety and Efficacy of Lithium in combination with Riluzole in ALS	National Institute of Health, ALS Association, ALS Society of Canada	Description of study
A 2-Part, Randomized, Double-Blind, Safety and Tolerability Study Evaluating KNS-760704 in Patients with Amyotrophic Lateral Sclerosis (ALS)	Knopp Neurosciences	Description of Study
Excercise and Oxidative Stress in ALS	National Institute of Health	Description of study
Efficacy of Using Cutometer Measurements as a Biomarker for the Progression of ALS	ArbesIdeas	Description of study
ALS Research Group DNA Banking Longitudinal Data Collection	National Institute of Health, Muscular Dystrophy Association, ALS Association	Description of study
ALS Genetic and Environmental Epidemiology	Muscular Dystrophy Association	Description of study
Cognitive Function in ALS	Wings over Wall Street, National Institute of Health
Modafinal for Fatigue in ALS	Research Foundation for Mental Hygiene
Early Treatment of ALS With Nutrition and NIPPV	National Institutes of Health
Clincial Trial of High Dose CoQ10 in ALS	National Institutes of Health
Combination Therapy Selection Trial	ALS Association Wings Over Wall Street (MDA) Ride for Life
Copaxone in ALS	Independently Funded
Diagnostic and Natural History Markers in Amyotrophic Lateral Sclerosis	National Institutes of Health
Improved Palliative and End-of-life Care	National Institutes of Mental Health
Minocycline in ALS	National Institutes of Health
Aeolus 10150	Aeolus Pharmaceuticals
Aeolus 10150 – A multiple Dose Study	Aeolus Pharmaceuticals
Skin Biopsies for Generation of ALS- Specific Human Embryonic Stem Cells	Project ALS	Description of study